In enzymology, a dUTP diphosphatase (EC 3.6.1.23) is an enzyme that catalyzes the chemical reaction. Bonda E, Rahav G, Kaya A, Bakhanashvili M. Oncotarget.

This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.

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This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. [4], This gene encodes an essential enzyme of nucleotide metabolism.  |  Manual assertion inferred by curator fromi, Manual assertion inferred from combination of experimental and computational evidencei, Manual assertion inferred by curator fromi, BioCyc Collection of Pathway/Genome Databases, BRENDA Comprehensive Enzyme Information System, Pathway Commons web resource for biological pathway data, Reactome - a knowledgebase of biological pathways and processes, SABIO-RK: Biochemical Reaction Kinetics Database, UniPathway: a resource for the exploration and annotation of metabolic pathways,

Manually curated information that is based on statements in scientific articles for which there is no experimental support.

○   Lettris Biochim Biophys Acta Mol Cell Res. Heterologous expression of anti-apoptotic human 14-3-3β/α enhances iron-mediated programmed cell death in yeast. Jouer, Dictionnaire de la langue françaisePrincipales Références. [5][6][7][10] DUT is also crucial for maintaining genome integrity by reducing cellular dUTP levels, thereby preventing the repeated cycles of uracil misincorporation into DNA and DNA repair-mediated strand breaks that would lead to cell death. Nuclear isoform 2 is phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2. The current subsections and their content are listed below:

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This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.

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This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is in its mature form or if it represents the precursor.

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This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). J Biol Chem. Toutes les traductions de dutp diphosphatase, dictionnaire et traducteur pour sites web. Lettris est un jeu de lettres gravitationnelles proche de Tetris. Get the latest research from NIH: https://www.nih.gov/coronavirus. using the generator polynomial: x64 + x4 + x3 + x + 1.  | Privacy policy Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. 2007 Dec 7;282(49):36010-23. doi: 10.1074/jbc.M704058200.  | Informations [1] Structural studies It is updated at every UniProt release.

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This section provides information on the tertiary and secondary structure of a protein.

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This subsection of the 'Structure' section is used to indicate the positions of experimentally determined beta strands within the protein sequence.

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This subsection of the 'Structure' section is used to indicate the positions of experimentally determined helical regions within the protein sequence.

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This subsection of the 'Structure' section is used to indicate the positions of experimentally determined hydrogen-bonded turns within the protein sequence. 2015 Jul 6;2(7):247-255. doi: 10.15698/mic2015.07.213. Of interest, cell death was not prevented under culture conditions modeling chronological aging, suggesting that DUT-M only protects dividing cells. This enzyme has a dual function: on one hand, it removes dUTP from the deoxynucleotide pool, which reduces the probability of this base being incorporated into DNA by DNA polymerases, while on the other hand, it produces the dTTP precursor dUMP.

A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.

[4] E2F and Sp1 enhance DUT expression by binding its promoter, while p53 inhibits DUT transcription by binding its promoter. Indexer des images et définir des méta-données. [7], DUT interacts with dUTP to catalyze its hydrolysis into dUMP and pyrophosphate.

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Participer au concours et enregistrer votre nom dans la liste de meilleurs joueurs ! Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993))

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In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.

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This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.

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This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. Epub 2019 Feb 1.

More information in the GO evidence code guide

, Inferred from biological aspect of ancestor,

Traceable Author Statement

The dUTPase of white spot syndrome virus assembles its active sites in a noncanonical manner. In enzymology, a dUTP diphosphatase (EC 3.6.1.23) is an enzyme that catalyzes the chemical reaction. USA.gov. This enzyme participates in pyrimidine metabolism. 2017 Dec;50:103-115. doi: 10.1016/j.jnutbio.2017.08.008. The anti-apoptotic function of DUT-M was confirmed by demonstrating that an increase in dUTPase protein levels is sufficient to confer increased resistance to H2O2 in cultured C2C12 mouse skeletal myoblasts. We use cookies to help provide and enhance our service and tailor content and ads. Using yeast as a model of eukaryotic mitochondrial apoptosis, we show that a cDNA corresponding to the mitochondrial variant of the human DUT gene (DUT-M) encoding the deoxyuridine triphosphatase (dUTPase) enzyme can prevent apoptosis in yeast in response to internal (Bax expression) and to exogenous (H2O2 and cadmium) stresses. Manual assertion inferred from combination of experimental and computational evidencei,

Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.

Evidence for a second messenger function of dUTP during Bax mediated apoptosis of yeast and mammalian cells. For example, the anti-apoptotic function of free radical scavenging proteins supports the pro-apoptotic function of Reactive Oxygen Species (ROS). This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All. Sci. The ligands are bound between subunits, and for each substrate molecule, residues from adjacent subunits contribute to the binding interactions. Of interest, cell death was not prevented under culture conditions modeling chronological aging, suggesting that DUT-M only protects dividing cells. Le service web Alexandria est motorisé par Memodata pour faciliter les recherches sur Ebay.

This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is in its mature form or if it represents the precursor.

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Sequence processingi: The displayed sequence is further processed into a mature form.

This subsection of the 'Function' section describes the metabolic pathway(s) associated with a protein.

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This subsection of the Function section describes the interaction between a single amino acid and another chemical entity. of multiple genes (paralogs).

[11], Since many chemotherapeutic agents such as 5-fluorouracil treat neoplastic diseases, including head and neck cancer, breast cancer, and gastrointestinal cancer, by targeting TS in thymidylate metabolism, DUT may protect against the cytotoxic side effects by countering dUTP accumulation. Zhou DR, Eid R, Miller KA, Boucher E, Mandato CA, Greenwood MT. With the final product ranging from thousands to millions of DNA copies, PCR is an extremely important part of medical and clinical research.

What is the canonical sequence?

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The checksum is a form of redundancy check that is calculated ○   Boggle. Manual assertion based on opinion ini, Online Mendelian Inheritance in Man (OMIM), neXtProt; the human protein knowledge platform, The Pharmacogenetics and Pharmacogenomics Knowledge Base, Pharos NIH Druggable Genome Knowledgebase, ChEMBL database of bioactive drug-like small molecules, BioMuta curated single-nucleotide variation and disease association database, Domain mapping of disease mutations (DMDM), jPOST - Japan Proteome Standard Repository/Database, MassIVE - Mass Spectrometry Interactive Virtual Environment, PaxDb, a database of protein abundance averages across all three domains of life, ProteomicsDB: a multi-organism proteome resource, iPTMnet integrated resource for PTMs in systems biology context, MetOSite database of methionine sulfoxide sites.

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