Proc. It is the most polyphyletic known enzyme: six distinct classes have been described, all catalyzing the same reaction but representing unrelated gene families with no known sequence or structural homology. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.
This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). [Full Text: http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=10915626], Hess, K. C., Jones, B. H., Marquez, B., Chen, Y., Ord, T. S., Kamenetsky, M., Miyamoto, C., Zippin, J. H., Kopf, G. S., Suarez, S. S., Levin, L. R., Williams, C. J., Buck, J., Moss, S. B.
Information which has been imported from another database using automatic procedures.Mapping a gene defect in absorptive hypercalciuria to chromosome 1q23.3-q24. The algorithm is described in the ISO 3309 standard. (from NCBI), Buck, J., Sinclair, M. L., Schapal, L., Cann, M. J., Levin, L. R.
The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) American journal of physiology. information that you need at your fingertips. from the sequence. Some G proteins switch adenylyl cyclase on, increasing cAMP production, while others switch it off. Buck et al. The version number for both the entry and the canonical sequence are also displayed.
This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).