FASEB J. doi: 10.1161/CIRCULATIONAHA.106.669697, Eisenstein, A., Patterson, S., and Ravid, K. (2015). Immunol. Proc. Physiol. Cell. 290, 338–349. J. Biol. doi: 10.1620/tjem.237.141, White, J. H., McIllhinney, R. A., Wise, A., Ciruela, F., Chan, W. Y., Emson, P. C., et al. Diabetes mellitus (DM) is the most common endocrine disorder; in 2014, 9% of all adults aged 18+ years were estimated to have diabetes (WHO, 2014), and by 2025, 300 million people worldwide will have the disease (Mane et al., 2012). Relative agonist potencies of C2-substituted analogues of adenosine: evidence for adenosine A2B receptors in the guinea pig aorta. 21, 2379–2388. Adenosine A(1) receptor in cultured neurons from rat cerebral cortex: colocalization with adenosine deaminase. Front. Moriyama and Sitkovsky reported that A2AAR coexpression with A2BAR improves the cell-surface expression of A2BAR, which is normally poor because A2BAR lacks a dominant forward-transport signal for export from the ER to the cell surface (Moriyama and Sitkovsky, 2010). This mechanism is clearly not mutually exclusive with the mechanism by which α-actinin-1 mediates A2BAR interaction with actin filaments and thereby modulates the trafficking and surface expression of A2BAR (Sun et al., 2016). Physiol. Pharmacol. 1. The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin. Rev. Enhanced mast cell activation in mice deficient in the A2B adenosine receptor. B., and Hellsten, Y. J. Neurochem. Adenosine A(2B) receptor mediates an increase on VEGF-A production in rat kidney glomeruli. (2014). 61, 77–94. doi: 10.1007/s11302-012-9350-3, Wen, J., Wang, B., Du, C., Xu, G., Zhang, Z., Li, Y., et al. J. Chem. 36, 916–924. Merighi S, Bencivenni S, Vincenzi F, Varani K, Borea PA, Gessi S. A2B adenosine receptors stimulate IL-6 production in primary murine microglia through p38 MAPK kinase pathway. Cancer Res 2014;74:3652-8. As they explain, the mechanisms thought to be involved in A2B-mediated tumour progression are multiple. J. Pharmacol. In ADA-deficient mice, a high level of adenosine in kidney tissues resulted in proteinuria and renal fibrosis, and treatment with A2BAR antagonists attenuated renal dysfunction and fibrosis (Dai et al., 2011). (2013). (2009). 37, 419–434. (2015). Rigorous studies from different laboratories have suggested a pivotal role of A2BAR in acute kidney injury. Thromb. Circulation 125, 354–363. Johnston-Cox, H., Eisenstein, A. S., Koupenova, M., Carroll, S., and Ravid, K. (2014). (2000). Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. The adenosine receptors present on the plasma membrane of chromaffin cells are of the A2B subtype. doi: 10.4049/jimmunol.0802193, Hasko, G., Csoka, B., Nemeth, Z. H., Vizi, E. S., and Pacher, P. (2009). J. Mol. Blood 112, 1822–1831. (2014). Rev. B. Commun. The impact of adenosine and A(2B) receptors on glucose homoeostasis. 116, 2173–2182. J. Biol. 75, 1–6. doi: 10.1073/pnas.0908801107, Stein, E., Zou, Y., Poo, M., and Tessier-Lavigne, M. (2001). J. Immunol. Mucosal Immunol 2015;8:1324-38. Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis. (2012). Vascul. 11. Physiol. 202, 9–20. J. Biol. Rivkees, S. A., and Reppert, S. M. (1992). doi: 10.1038/sj.bjp.0706180, Patel, L., and Thaker, A. 230, 2891–2897. Nephrol. (2008). Res. 56, 705–713. In this work they analyse the oncogenic role of the A2B receptor, also proposing and discussing its targeted blockade as a new anti-cancer therapeutic option. U.S.A. 102, 9583–9588. 189, 4566–4573. 4:37. doi: 10.3389/fchem.2016.00037. B., IJzerman, A. P., Jacobson, K. A., Linden, J., and Muller, C. E. (2011a). doi: 10.1161/01.RES.0000061572.10929.2D, Figler, R. A., Wang, G., Srinivasan, S., Jung, D. Y., Zhang, Z., Pankow, J. S., et al. Cell Host Microbe 15, 339–350. Rev. Growing evidence indicates that A2BAR potentially plays a pathophysiological role in human cancer and might serve as a target for novel therapies or cotherapies for cancer. In this review, we discuss our current understanding of the cellular functions of A2BAR and their implications for the pathogenesis of several human diseases. Figure 1. Cell Res. Expert Rev Anticancer Ther 2017;17:527-35.

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